A influência dos antioxidantes no controle glicêmico em pacientes com Diabetes Mellitus tipo 2

Abstract

Type 2 Diabetes Mellitus (DM) is also characterized by insulin resistance, resulting in depletion of the cellular antioxidant defense system secondary to increased oxidative stress which is an early induced process in the presence of high glycemia, followed by activation of other pathways cells that compete for cellular damage and dysfunction. The aim of the present article was to demonstrate the influence of antioxidants such as vitamin A, vitamin D, vitamin E and coenzyme Q 10 on glycemic control in patients with type 2 DM. This study consists of a descriptive review bibliography of articles published in the period between 2008 and 2018, using the database PudMed, Google Scholar and Scielo. Thus, the decoding of the correlated data was grouped by similarities, allowing the construction of categories of analysis of the studies carried out with the objective of inducing glycemic control related to antioxidants. It was possible to demonstrate in the present review article a lower risk of dysglycemia, benefits in glycemic control, insulin resistance, fasting glycemia, glycated hemoglobin and even possible delay in the development of DM regarding the use of the mentioned antioxidants, however more studies still need be performed in order to confirm the efficacy of antioxidants in glycemic control and their safety regarding long-term supplementation.