A insuficiência da vitamina D nos pacientes portadores de artrite reumatoide e o impacto na qualidade de vida: revisão de literatura

Abstract

Rheumatoid Arthritis (RA) is an autoimmune disease that affects women in a greater proportion. This literature review aims to relate vitamin D insufficiency to the quality of life of patients with this disease. Methodology: This is a bibliographical search in the databases: Pubmed, Scielo and google acadic, through a qualitative exploratory method, for which 15 articles were selected, including: meta-analysis studies, systematic reviews and articles. Original articles, which are described in the Portuguese and English references, dated from 1999 to 2019. Discussion: Rheumatoid arthritis is a disease that produces an immunological reaction against the organism itself, where there is involvement and inflammation of the synovial membrane. mainly the peripheral joints. Vitamin D deficiency can occur in patients with RA and other autoimmune diseases, contributing to their decreased quality of life. Evidence suggests that vitamin D supplementation may play an important role in regulating the immune system and probably in the prevention of autoimmune diseases. However, there is no association with disease activity or pain reported by patients. In addition, increased serum vitamin D levels associated with calcium supplementation may contribute to the onset of cardiovascular disease and increased mortality rates related to these diseases. Conclusion: Vitamin D supplementation may aid in better control of RA, given its ability to suppress inflammation in autoimmune diseases. This contributes to a better quality of life of patients diagnosed with the disease. However, although scientific studies have beneficial effects of vitamin D supplementation on autoimmune diseases, further clinical studies will be needed to determine if its use is associated with lower mortality from various causes.