A utilização do plasma rico em plaquetas em feridas contaminadas e infectadas de equinos

Abstract

Platelet-Rich Plasma (PRP) is an autologous therapy consisting of a concentrated suspension of centrifuged blood containing Growth Factors (GF) derived from the patient's own platelets to stimulate wound regeneration. This plasma enhances tissue regeneration by affecting cell recruitment, proliferation, and differentiation. Studies have shown that PRP can be effective in repairing musculoskeletal and skin injuries in several species, with promising results. When applied topically to skin wounds, it can be particularly effective due to its high concentration of coagulation factors, leukocytes that confer natural resistance to infectious and immunogenic agents, and platelets that release GF, which results in local debridement and antibacterial activity. Thus, the objective is to analyze the efficacy and review the literature on PRP in the healing progression of contaminated cutaneous wounds with topical application in gel form in horses. It highlights its clinical applicability, benefits, limitations, and prospects. Six animals were used to carry out the study, and a standardized application protocol was applied every 48 hours for evaluation. The results obtained were promising, making it possible to achieve the objective of evaluating the evolution of wound healing.