Please use this identifier to cite or link to this item: https://repositorio.ucb.br:9443/jspui/handle/123456789/7457
metadata.dc.type: Artigo
Title: Tumour necrosis factor production in vivo and in vitro in response to Paracoccidioides brasiliensis and the cell wall fractions thereof.
Authors: Cavalcanti Neto, Florêncio Figueiredo
Alves, L. M. C.
Silva, Celio Lopes
Abstract: Tumour necrosis factor (TNF) was detected in serum from mice challenged with Paracoccidioides brasiliensis. The serum TNF levels of mice challenged with an avirulent strain were significantly higher than those of mice challenged with a virulent strain, and the same was observed for the TNF levels of mice challenged with a cell wall fraction (Fl) from the two fungal strains. Fraction F1 consisted of chitin and fl-glucan; but although the chitin contents were similar for the two strains, the avirulent strain allowed a greater content of fl-glucan. The fl-glucan, purified from both strains, increased serum TNF levels in an identical dose-dependent manner, whereas purified chitin did not induce serum TNF levels. P. brasiliensis, the Fl fractions and f,-glucan induced macrophages to secrete TNF in vitro. The differences in TNF levels, induced by the different fungal strains, were correlated with the f-glucan concentrations in the cell walls of both the avirulent and virulent strains of P. brasiliensis. These findings support a role for TNF in the pathogenicity of P. brasiliensis.
Keywords: Paracoccidioidomycosis
Paracoccidioides brasiliensis
tumour necrosis factor beta-glucan
Citation: FIGUEIREDO, F. ; ALVES L.M.C. ; Silva, Célio L. Tumour necrosis factor production in vivo and in vitro in response to Paracoccidioides brasiliensis and the cell wall fractions thereof. Clinical and Experimental Immunology, v. 93, n. 2, p. 189-194, 1993
metadata.dc.rights: Acesso Aberto
URI: http://hdl.handle.net/123456789/220
https://repositorio.ucb.br:9443/jspui/handle/123456789/7457
Issue Date: 1993
Appears in Collections:PPG - Revistas e Artigos Científicos



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